Within two frenetic hours, Csaba Laszlo had been sacked after 18 months in charge and Jefferies was swiftly back at the helm following a nine-year absence.
After a brief meeting with players on Friday evening, Jefferies immediately assumed control the following day for the 1-0 defeat at St Johnstone and again held a team gathering on Sunday.
There has simply been no let-up for the 59-year-old, with a hugely-important CIS Cup semi-final against the Buddies now on the agenda as Jefferies seeks to steer his injury-ravaged team to a first final in four years.
The former Kilmarnock manager wants time to stamp his authority on his return, but he knows fans will not be so patient as they seek a Hampden date next month against either Rangers or St Johnstone.
He said: "It's come very hectic, Friday night and then a game on Saturday.
"I've got to know the players a bit better and we'll look to pick what we think is the strongest side available and hopefully get through to a final.
"But it's going to take a few weeks to get to know everyone. It's different to when I was last here, there are far more staff about for a start. But that's progress, football moves on.
"I thought Csaba did a terrific job here, had his way of doing things, but everybody is different and we have to adapt now how we go about things.
"It will take time, everybody is a bit apprehensive and that is normal.
"We'll endeavour to work hard to get this club right. Players are going to find a change, because everybody does it differently.
"But I have been in the game a long time. Different routines might just spark something.
"The fans have always had high expectations and we've got to try and give them success."
Jefferies, who steered Hearts to Scottish Cup glory in 1998, watched a patched-up side lose at McDiarmid Park and again has injuries to contend with in Lanarkshire.
But he will have no hesitation in calling on the club's group of youngsters if required.
Jefferies added: "I think there is a good crop here, maybe a little bit less experienced than the ones I brought through last time.
"But the club has a great name for pushing youngsters through and as time goes on I'll be trying to make sure that tradition is kept.
"If we can get a win tomorrow night it will make the next few days a lot more enjoyable, as I can get a bit of time to do things."
Jefferies has held brief discussions with owner Vladimir Romanov since his appointment, with his desired backroom team of trusted duo Billy Brown and Gary Locke high on the agenda.
Both assisted Jefferies in Perth without being officially on staff and he added: "I'll be delighted if they come here and there is every chance.
"We sat down on Sunday and the club said to me that they'll do everything they can to bring them on board.
"I know how Billy works and Gary, who is doing his coaching badges, is a good link to the dressing room."
Source: Team Talk