Andrew Driver, Ruben Palazuelos, Scott Robinson, Craig Thomson, Johnny Stewart, Ismael Bouzid, Jamie MacDonald and David Templeton are all out.
Alex Neil and James Wesolowski should return for Accies and Nicky Riley could but Dougie Imrie is suspended and Mickael Antoine-Curier remains injured.
Hearts (from): Kello, L Wallace, Zaliukas, Kucharski, J Thomson, Jonsson, Black, Obua, Stevenson, Kingston, Balogh, Suso, Smith, Nade, R Wallace, Glen, Novikovas, Elliot, Mulrooney, Balatoni.
Hamilton (from): Cerny, Elebert, Van Zanten, Canning, Easton, Sullivan, Crawford, McLaughlin, Mensing, McArthur, Wilkie, Thomas, Kirkpatrick, M Paixao, Murdoch, Elliott, F Paixao, Wesolowski, Neil, Riley.
Source: BBC Sport